Happy Cat??

By Dr. Karen Becker and comments by Diane Weinmann

 

How to Create a Happy Cat

In addition to feeding a nutritionally optimal, species-appropriate diet, keeping kitty at a lean-and-healthy weight, and providing exercise incentives, there are several components to her indoor environment that you’ll need to consider from her uniquely feline perspective. These include:

  1. Litterbox location — In the wild, cats not only hunt prey, they are prey for other animals. Certain activities make them vulnerable to predators, including eliminating. This vulnerability is what causes anxiety in your kitty when her litterbox is in a noisy or high traffic area.

Your cat’s “bathroom” should be located in a safe, secure location away from any area that is noisy enough to startle her or make her feel trapped and unable to escape.

  1. The opportunity to “hunt” for meals and snacks — Your cat, while domesticated, has maintained much of his natural drive to engage in the same behaviors as his counterparts in the wild, including hunting for food, which also happens to be excellent exercise. A great way to do that with an indoor cat is to have him “hunt” for his meals and treats.

Separate his daily portion of food into three to five small meals fed throughout the day in a variety of puzzle toys or indoor hunting feeder mice (available for raw and canned food, too!). You can also hide his food bowls or food puzzle toys in various spots around the house.

  1. Places for climbing, scratching, resting, and hiding — Cats are natural climbers and scratchers, and those urges don’t disappear when they move indoors. Your cat also needs her own resting place and a hiding place where she feels untouchable.

Cats prefer to interact with other creatures (including humans) on their own terms, and according to their schedule. Remember: well-balanced indoor kitties are given the opportunity to feel in control of their environment. Jackson Galaxy has written several books on creating feline environmental enrichment around the home that I highly recommend.

  1. Consistency in interactions with humans — Your cat feels most comfortable when his daily routine is predictable, so performing little rituals when you leave the house and return can help him feel more comfortable with your comings and goings. A ritual can be as simple as giving him a treat when you leave and a nice scratch behind the ears as soon as you get home.

Playtime should also be consistent. Learn what types of cat toys he responds to and engage him in play, on his timetable. Of course, while you can encourage him to play, it’s pointless to force the issue. Oh, and when he’s had enough, he’s had enough!

  1. Sensory stimulation — Visual stimulation: Some cats can gaze out the window for hours. Others are captivated by fish in an aquarium. Some even enjoy kitty videos.

Auditory stimulation: When you’re away from home, provide background noise for kitty that is similar to the ambient sounds she hears when you’re at home, for example, music or a TV at low volume. Olfactory stimulation: You can stimulate your cat’s keen sense of smell with cat-safe herbs or synthetic feline pheromones (e.g., Feliway).

All in all, paying attention to your kitty, interacting and talking with them will go a long way to ensure their happiness. Provide stimulation—you get bored right?  Well, they will to!   If they seem upset or sad consider what may have changed in their life or environment to have caused their issue.  When all else fails, contact Diane who is an animal communicator at dianefortheloveofanimals@yahoo.com.

 

Thyroid Dysfunction

By Dr. Dodds DVM

Thyroid Dysfunction is the most frequently recognized endocrine disorder of pets and it’s often difficult to make a definitive diagnosis, since many clinical signs mimic those resulting from other causes.

 

Dogs

Hypothyroidism is the most common endocrine disorder of canines. Nearly 90 percent of canine cases result from autoimmune thyroiditis. The heritable nature of this disorder poses significant genetic implications for breeding stock.
Common symptoms to look for in dogs:

  • Scratching  •  Hair loss  •  Seizures  •  Chronic bowel issues • Seizures in adulthood  •  Chewing feet and skin  •  Skin and ear infections  • Behavioral changes: aggression, moodiness, phobias

Cats
Hyperthyroidism in readily induced, especially in geriatric cats, by feeding commercial pet foods, treats and snacks containing excessive amounts of iodine. This finding has led to a major change in the iodine formulations of feline commercial pet foods.

Common symptoms to look for in cats:
Pacing  •  Anxiety  •  Phobias   •  Howling  •  House soiling  • Insatiable hunger  •  Dementia with aging  •  Hunger and weight loss

How to give your indoor cat the best of both worlds

By Dr. Karen Becker and comments by Diane Weinmann

 

Not long ago at a veterinary conference, a Dr. Margie Scherk, a vet from Vancouver, Canada with a feline practice, spoke on the topic of lifestyle risks of indoor versus outdoor cats. One of her points was that while many people believe responsible cat owners keep their pets indoors, “The fact is that cats have not been selectively bred to be indoors 24 hours a day, and many don’t adjust to living in close contact to people — they’re forced to.”1

Lifestyle risks of indoor cats

According to Scherk, who cites a 2005 study published in the journal Applied Animal Behaviour Science,2 the following are risks to cats who live entirely indoors:

Lower urinary tract diseases Boredom
Hyperthyroidism Household hazards (burns, poison exposure, falls)
Obesity Inactivity, decreased fitness
Diabetes Behavior problems (spraying, scratching, obsessive behavior)
Odontoclastic resorptive lesions Dermatologic problems (atopic dermatitis, acral lick dermatitis)

Lifestyle risks of indoor-outdoor and outdoor-only cats

Thanks to KittyCams, researchers have been able to learn plenty about the kinds of risky business free-roaming cats get up to when they’re wandering around outdoors, including:3

Trauma (usually involving being hit by a vehicle) or human abuse Entering storm drains
Parasites Climbing trees
Crossing roads Climbing on roofs
Having non-aggressive contact with unfamiliar cats (infectious disease risk) Having contact with wild animals (injury and disease risk)
Consuming solids or liquids left by owners, baits Crawling into car engines

Cats are also prey for wildlife such as coyotes, mountain lions, wolves and raptors, and fights among outdoor cats can also lead to serious injury and infections, including bite abscesses. Sadly, cruel humans also pose a grave risk to cats through gunshots, poisonings, burnings and asphyxia.4

Infectious diseases, several of which are zoonotic (can be spread to humans) commonly sicken and kill outdoor cats, including feline retroviruses, mycoplasmosis, toxoplasmosis, bartonellosis (cat scratch fever), tularemia, plague and rabies, along with worms, ectoparasites and fungal infections.

Best of both worlds: Cats should live indoors and also spend safe, supervised time outdoors

Given the risks associated with living entirely indoors, Scherk believes it should be the goal of veterinarians to encourage people to make indoor living more suitable for cats by decreasing stressful stimuli and enriching and improving the environment.

I certainly agree. I tend to think of cats like humans; we live in protected, safe environments indoors, but enjoy going outside, and spending lots of time outside, in safe environments. Living indoors all the time isn’t what most cats would choose, nor is it an entirely natural environment for them, but it’s by far the safest life we can choose for them. Letting them roam free outdoors some or all of the time presents much more risk.

But just because your kitty lives inside doesn’t mean she can’t go on supervised visits outside to bask in the sun, exercise and ground herself on a daily basis. Outdoor adventures are wonderful for cats, as long as they’re safe.

I recommend walking your cat in nice weather using a harness. This gets him out into the fresh air, stimulates his senses and gets his paws in direct contact with the ground. An alternative is a safe, fully enclosed catio that prevents him from getting out and other animals from getting in. Many cats with catios spend the majority of their days outside, but safe.

Diane tried walking her cat once but the kitty was so scared she had to bring him back inside so this outdoor experience doesn’t always work; however, some cats love it especially in enclosed strollers!

How to provide your cat with an optimal life indoors

  • Enrich the indoor environment — The term “environmental enrichment” means to improve or enhance the living situation of captive animals to optimize their health, longevity and quality of life. The more comfortable your cat feels in your home, the lower her stress level. Reducing stress is extremely important in keeping cats physically healthy.

Enriching your kitty’s surroundings means creating minimally stressful living quarters and reducing or eliminating changes in her life that cause anxiety. Jackson Galaxy has written several books on creating feline environmental enrichment around the house that I highly recommend.

The essentials of your cat’s life — food, water and litterbox (which should be kept scrupulously clean), should be located in a safe, secure location away from any area that is noisy enough to startle her or make her feel trapped and unable to escape. Your cat also needs approved places for climbing and scratching (natural feline behaviors) in her indoor environment, as well as her own resting place and a hiding place where she feels untouchable.

Think about what you can do to appeal to your kitty’s visual, auditory and olfactory senses. For example, some cats can gaze out the window for hours, while others are captivated by fish in an aquarium. Some even enjoy kitty videos.

When you’re away from home, open all your shades and blinds to provide natural light during the day. Provide background noise for kitty similar to the ambient sounds she hears when you’re at home, for example, nature music or a TV at low volume. You can stimulate your cat’s keen sense of smell with cat-safe herbs or synthetic feline pheromones.

  • Make sure he gets daily exercise — Consistent daily exercise, including at least 20 minutes of high-intensity activity will help your cat burn fat and increase muscle tone. Make sure he has things to climb on, like a multilevel cat tree or tower. Think like a cat and choose toys and activities that answer his need for hunting, stalking and pouncing on “prey.” One of Diane’s friends had stairs created going up a wall so the cats could jump from one to another or just sit on them! Ingenious!

Because our cats don’t have the freedom they would in the wild, it’s up to us to give them opportunities to practice those natural instincts. A great way to do that is to have your kitty “hunt” for his food. Try separating his daily portion of freeze-dried raw food into three to five small meals fed throughout the day in a variety of puzzle toys or indoor hunting feeder mice, or load them with a small piece of tasty, dehydrated meat treat.

This will encourage him to “hunt” and eat on a schedule similar to his wild cousins, and as an added bonus, he might just sleep through the night thanks to the puzzle toy you give him at bedtime.

  • Feed a moisture-rich, nutritionally balanced, species-appropriate diet — Offering your cat an optimal diet is the single most important thing you can do to help her have a long, healthy life. That’s why it’s important to understand that some foods are metabolically stressful, for example, all dry (kibble) formulas, processed pet food (canned or dry) containing feed-grade (versus human-grade) ingredients and diets containing grains, potatoes or other starches.

The nutrition that generates the least amount of metabolic stress for most cats, regardless of age, is their ancestral diet: whole, raw (or gently cooked), unprocessed, organic, non-GMO and in its natural form. Animal meat should be the foundation of your kitty’s diet throughout her life. Filtered, pure, fresh water in nontoxic metal or glass (not plastic) bowls is also important.

  • Keep your cat at a healthy weight — Tragically, the majority of cats in the U.S. are overweight or obese. The obesity-related diseases overweight kitties inevitably acquire shorten their lifespans and often destroy their quality of life along the way. If you want your kitty by your side and able to get around comfortably for 20 years, one of the worst things you can do is encourage him to get fat.

The first step in keeping your cat at a healthy weight is to feed an optimal diet as I described above. It’s equally important not to free-feed. It’s also important to calculate kcal (kilocalorie) requirements for your cat’s ideal weight and include treats in his total daily calorie count.

  • Schedule regular veterinary wellness exams — I recommend twice-yearly wellness visits because:

◦Changes in your kitty’s health can happen rapidly, especially on the inside where you can’t see it, like sudden changes in kidney health

◦Sick cats often show no signs of illness, but early detection allows for early intervention

◦Semi-annual visits give you and your veterinarian the opportunity to closely monitor changes in your kitty’s behavior and attitude that require further investigation

At a minimum, younger healthy cats should see the vet once a year. Kitties over the age of 7 and those with chronic health conditions should be seen twice a year or more frequently if necessary. If your cat hates car travel, consider a mobile vet who makes house calls.

I recommend that you find a veterinarian whose practice philosophy you’re comfortable with. This may be a holistic or integrative veterinarian, or a conventional veterinarian who doesn’t aggressively promote vaccines, pest preventives or veterinary drugs at every visit. House call vets can also be a great, lower stress option for indoor kitties.

Generally speaking, if you’re dealing with a conventional vet, you’ll need to advocate for your cat and push back as necessary, politely but firmly. Always remember that you have the final say in what treatments and chemicals are administered to your pet.

 

An integrative approach to chronic kidney disease (CKD) in cats

By: Barbara Fougere, BSc, BVMS (Hons), BHSc (Comp Med), MODT, MHSc (Herb Med), CVA, CVCP, CVBM

CKD is a common but manageable condition in feline patients, and responds well to integrative medicine. Herbs and acupuncture are key therapies.

Chronic kidney disease (CKD) is a common problem in cats, and one which all veterinarians encounter in practice. An integrative approach that includes herbs and acupuncture can help treat and even reverse this condition in feline patients.

CKD can be detected early through careful monitoring at annual wellness programs. IRIS (International Renal Interest Society) staging allows for the conventional staging of treatment, including any dietary changes. Key treatment strategies for feline CKD include supporting hydration, reducing phosphorus (usually through protein restriction), regulating blood pressure and controlling calcium levels. The intensity of intervention increases with disease progression.

Integrative treatment goals

Using integrative approaches to CKD, we have observed cats moving from IRIS Stages 2 and 3 to Stage 1, and remaining there for years. This reversal implies that nephrons are hypoxic and under-functioning, and that improving their functional capacity is a key goal. See below for integrative treatment goals for CKD.

Herbs can optimise kidney cell function by reducing oxidative stress, improving renal blood flow and mitigating fibrosis, thereby maintaining patients in early stages for extended periods. Acupuncture, manipulative therapies and other modalities can also be a part of the integrative approach.

With acute renal disease, the goals are modified to regulate/decongest the kidneys by reducing blood flow, and provide anti-inflammatory support to inflamed glomeruli. This may be a starting point with pyelonephritis, for example. Most cats, however, benefit from increased perfusion unless the renal disease is acute in onset (inflammatory).

Dietary considerations

Despite numerous experimental studies and clinical trials, questions about feeding protein to cats with chronic kidney disease (CKD) remain. What is the optimal amount of protein for a cat with CKD? How much restriction is necessary? Do different types of kidney disease require different dietary therapies? At what point in disease progression should protein restriction be implemented? Does the type of protein make a difference? Does every meal have to be restricted? Will a cat in IRIS Stage 3 or 4 benefit if phosphorus is restricted by other means? Might some cats with advanced disease benefit from increased protein levels?1 These concerns remain despite the common practice of prescribing therapeutic renal diets to cats in any stage of CKD.

Integrative practitioners provide, or are requested to provide, natural feeding advice to cat owners. Excellent resources include the veterinary Diplomats in Nutrition; Balance It and several software programs that can be used for formulating diets while taking feline preferences into account. See page xx for an example of a low-phosphorus diet for cats with CKD.

From an integrative perspective, real food is considered to have many benefits, including palatability for ill cats, and these benefits may outweigh those offered by processed foods. In IRIS Stage 1 and early Stage 2, the diet may not need to be modified, although serum phosphorus and the phosphorus content of the diet should be evaluated. From late Stage 2 onwards, consideration may be given to reducing protein by diluting with fat and carbohydrates.

Herbal help

Herbs can delay the onset and progression of CKD in cats by improving mitochondrial function, and providing antioxidant protection and ACE-inhibiting effects. Many herbs are anti-inflammatory, anti-fibrotic and nephroprotective, and several improve renal blood flow. A principle of herbal medicine is that formulations containing multiple plants can have greater effects than the same herbs taken separately. These synergistic effects enhance the desired action.2

Following are several herbs to be considered and included in formulas for renal treatments.

1. Rehmannia glutinosa

Rehmannia glutinosa occurs in many Chinese herbal formulas, including Rehmannia Eight Combination (Shen Qi Wan, Jin Gui Shen Qi Wan, Ba Wei Di Huang Wan), which is very useful for cats with CKD and weight loss, loss of strength, polyuria, polydipsia, and that are seeking warmth. It is also included in Zhi Bai Di Huang Wan, which is useful in cats with CKD and hyperthyroidism, particularly in those tending towards constipation, agitation and weight loss, along with polydipsia and polyuria.

Rehmannia has a long history of research and effective use in CKD. In humans, studies have found that it has a 91% efficacy in reducing renal damage from nephritis, due to the enhancement of renal blood flow and glomerular filtration.3 In a model of renal ischemia, ligated rats that received Rehmannia extract showed improved renal blood flow (to near normal levels) and reduced mortality and hypertension compared to controls, through either ACE inhibition or juxtaglomerular desensitization.4 Rehmannia reduces oxidative stress and can promote red blood cell production through bone marrow stimulation; reduce serum creatinine and urinary protein excretion and glomerulosclerosis in compromised patients; and inhibit the expression of Angiotensin II as well as Type IV collagen in the renal cortex.5, 6

Fresh Rehmannia is utilised in Ba Wei Di Huang Wan and Zhi Bai Di Huang Wan. Interestingly, a recent study supports the use of fresh over prepared Rehmannia; the former acts more powerfully on attenuating interstitial fibrosis by downregulating the expressions of transforming growth factor, a smooth muscle actin, and Type 1 collagen.7

2. Astragalus membranaceus

Astragalus membranaceus is known as a Qi tonic in Chinese medicine, and as a major immune-modulating herb in Western herbal medicine. It should also be known as a major kidney herb. Its major constituent, astragaloside, ameliorates renal interstitial fibrosis in vivo by inhibiting inflammation.8 It has major antioxidant effects.9 Astragalus has been reviewed by Cochrane and was found to offer some promising effects in reducing proteinuria and increasing haemoglobin.10 Its nephroprotective effects against oxidative stress include anti-inflammatory and anti-apoptotic mechanisms.11 In a systematic review of Astragalus on diabetic nephropathy in animal models, this herb was able to reduce blood glucose and albuminuria levels and reverse the glomerular hyperfiltration state, thus ameliorating pathologic changes.12

3. Angelica sinensis

Angelica sinensis contains polysaccharides that inhibit oxidative stress injury in mouse kidneys.13 Like Astragalus, its nephroprotective effects include anti-inflammatory and anti-apoptotic mechanisms.11 Renal microvascular lesions can contribute to the progression of glomerular sclerosis and tubulo-interstitial fibrosis in chronic kidney Both Astragalus and Angelica can improve microvascular lesions by increasing local renal blood flow to lessen hypoxic renal injury, promoting the recovery of renal blood flow and glomerular filtration rate after ischemia-reperfusion; modulating the imbalance of vaso-activators such as nitric oxide and angiotensin; increasing the expression of vascular epithelial growth factor; inhibiting the release of the intracellular calcium ion; and promoting DNA synthesis in endothelial cells to improve the function of endothelial cells. The evidence suggests that both herbs may retard the progress of renal diseases through the above-mentioned mechanisms.14

In one study involving rats with an obstructive uropathy, Astragalus and Angelica were administered with Enalapril and compared to monotherapy. Enalapril with Astragalus and Angelica decreased tubulointerstitial fibrosis to a significantly greater extent than did treatment with Enalapril alone.15

4. Cinnamon

Cinnamon is readily accepted by cats and offers a mono-herbal treatment for fussy felines. It occurs in the Wei Ling Tang formula, which is useful for overweight CKD cats with proteinuria, hematuria, urolithiasis, azotemia, glomerulonephritis and pyelonephritis. Cinnamon can inhibit advanced glycation end products (AGE) and can ameliorate AGE-mediated pathogenesis in diabetic nephropathy.16 Cinnamon is a major antioxidant and anti-inflammatory spice, and has had over 178 papers published on it from 1995 to 2015.17 Cinnamon at a dose of 50 mg/kg for two weeks was given to dogs; the systolic blood pressure and heart rate in the treated dogs was significantly lower than in the normal group.18

5. Silybum marianum

Silybum marianum is one of our preeminent nephron-protective herbs. It should be considered an adjunct to ameliorative potential effects against drug-induced kidney disease, particularly in chemotherapy.19 It is also an herb that could be considered for CKD support. It is a potent antioxidant and free radical scavenger that inhibits lipid peroxidation and stabilizes cell membranes. It also increases intracellular glutathione, which plays a crucial role in the body’s antioxidant capacity, and it has anti-inflammatory properties inhibiting T-cell proliferation and cytokine secretion.20 There is also evidence that Silybum has a regenerative effect on renal tissue after injury.21

Mushrooms — Ganoderma and Cordyceps

Mushrooms are well tolerated by cats when given in the form of powders or concentrated tinctures added to food. Ganoderma lucidum is a medicinal mushroom that has been widely used in China and Japan for hundreds of years for its immune-modulating, anti-inflammatory and anti-tumor effects. Ganoderma compounds are renoprotective.22.The active peptide in Ganoderma counteracts oxidative stress from renal ischemia, and in an animal model of diabetic nephropathies has renal protective effects.23

Likewise, Cordyceps sinensis is extensively used by Chinese physicians to treat chronic renal diseases and to stimulate the immune system. It also displays anti-oxidative activities. It is commonly used in renal transplant patients; it has been shown to significantly improve renal fibrosis.24

Acupuncture and moxibustion

A recent single blinded randomized controlled study in patients with CKD showed that acupuncture at bilateral LI4, ST36 and KI3, and electroacupuncture to right ST36 and KI3 and left ST36 and KI3, once a week for 12 weeks, led to reduced creatinine levels and increased glomerular filtration rates.25 Moxibustion at Bl 23 in patients with CKD reduced renal vascular resistance.26

Most of the benefits that acupuncture offers in renal failure are undoubtedly due to the ability of these points to manipulate blood flow. Local blood flow is manipulated using BL23, BL22 and GB25, while systemic blood flow is manipulated with GB34, BL40 and KI3. Systemic blood flow greatly impacts renal function. Peripheral vasoconstriction can be induced to drive more blood to the kidneys. Peripheral vaso-relaxation can be induced to decongest the kidneys.

For animals in Stage II renal failure (using the IRIS classification system), and particularly where UPC ratios are greater than 2.5, use GB25, BL22 and GB34. These animals will typically have benefited from hypotensive drugs and low-protein diets, but won’t show an immediate improvement from fluid therapy. For animals in Stage I renal failure, or where UPC ratios are less than 2 to 2.5, use KI3, BL40 and BL23. These animals will typically not benefit from low-protein diets and hypotensive drugs, but will show an overt improvement from fluids.27

Integrative treatment goals for feline CKD

·         Mitigate oxidative stress by using antioxidant herbs

·         Improve renal perfusion (in most cases)

·         Prevent fibrosis, which is a natural consequence of renal disease

·         Optimise systemic health and well-being

Example of a low-phosphorus diet for cats with CKD

·         50 grams or ¼ cup pearl barley

·         200 grams raw chicken breast meat

·         10 grams chicken liver

·         1 large egg yolk

·         2 cups raw sweet potato

·         4 teaspoons salmon oil plus 4 teaspoons flaxseed oil

Cook barley, sweet potato, chicken and liver are on low heat with water. When warm, mix in egg yolk to lightly cook it (and preserve the choline). When cool, the recipe is divided into four meals (average 250 kcals) with the addition of 1 teaspoon of salmon oil and 1 teaspoon of flaxseed oil daily. The meals are divided.

The whole recipe provides 1,029 kcal, 36% carb, 40% fat, 24% protein and 724 mg of phosphorus. It needs to be supplemented as it is low in a number of minerals and vitamins, and is still low in choline. Any supplement added should be evaluated for its phosphorus content. This should demonstrate the complexity of balancing diets. Another excellent strategy is to have several recipes and vary the composition of diets over time. More protein can be utilised alongside phosphorus binders in later stages of kidney disease.

Conclusion

Chronic kidney disease in cats is a manageable condition that responds well to integrative medicine. In the author’s experience herbal medicine and acupuncture are key. Many integrative practitioners have reported success with other additional therapies, including homeopathy, cell salts, flower essences and osteopathy.

References

1Larsen JA. “Controversies in Veterinary Nephrology: Differing Viewpoints: Role of Dietary Protein in the Management of Feline Chronic Kidney Disease”. Vet Clin North Am Small Anim Pract. 2016 Nov;46(6):1095-8.

2Bangar OP, Jarald EE, Asghar S, Ahmad S. “Antidiabetic activity of a polyherbal formulation (Karnim Plus)[J]”. Int J Green Pharm, 2009, 3(3) : 211-214.

3Su ZZ, He YY, Chen G. “Clinical and experimental study on effects of man-shen-ling oral liquid in the treatment of 100 cases of chronic nephritis”. Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. 1993;13(5): 259–260,269–272.

4Yi NY, Chu W, Koang NK. “Pharmacologic studies on Liu Wei Di Huang Wan: its action on kidney function and blood pressure of rats with renal hypertension”. Chin Med J-Peking. 1965;84(7):433–436.

5Yuan Y, Hou S, Lian T, Han Y. “Rehmannia glutinosa promotes the recovery of RBC and Hb levels in hemorrhagic anemia by promoting multiplication and differentiation of CFU-S and CFU-E bone marrow cell line”. Chung Kuo Chung Yao Tsa Chih. 1992;17(6):366–368.

6Lee BC, Choi JB, Cho HJ, Kim YS. “Rehmannia glutinosa ameliorates the progressive renal failure induced by 5/6 nephrectomy”. J Ethnopharmacol. 2009;122(1):131–135.

7Liu DG, Zeng M, Gao HY, et al. “Rehmanniae Radix and Rehmanniae Radix Praeparata Ameliorates Renal Interstitial Fibrosis Induced by Unilateral Ureteral Occlusion in Rats and Their Mechanism”. Zhong Yao Cai. 2015 Dec;38(12):2507-10.

8Zhou X1, Sun X1, Gong X1. “Astragaloside IV from Astragalus membranaceus ameliorates renal interstitial fibrosis by inhibiting inflammation via TLR4/NF-кB in vivo and in vitro”. Int Immunopharmacol. 2017 Jan;42:18-24.

9Shahzad M, Shabbir A, Wojcikowski K. “The Antioxidant Effects of Radix Astragali (Astragalus membranaceus and Related Species) in Protecting Tissues from Injury and Disease”. Curr Drug Targets. 2016;17(12):1331-40.

10Zhang HW1, Lin ZX, Xu C, et al. “Astragalus (a traditional Chinese medicine) for treating chronic kidney disease”. Cochrane Database Syst Rev. 2014 Oct 22;(10):CD008369.

11Shahzad M1, Small DM2, Morais C. “Protection against oxidative stress-induced apoptosis in kidney epithelium by Angelica and Astragalus”. J Ethnopharmacol. 2016 Feb 17;179:412-9.

12Zhang J1, Xie X, Li C, et al. “Systematic review of the renal protective effect of Astragalus membranaceus (root) on diabetic nephropathy in animal models”. J Ethnopharmacol. 2009 Nov 12;126(2):189-96.

13Fan YL, Xia JY, Jia DY. “Protective effect of Angelica sinensis polysaccharides on subacute renal damages induced by D-galactose in mice and its mechanism”. Zhongguo Zhong Yao Za Zhi. 2015 Nov;40(21):4229-33. [Article in Chinese].

14Song JY1, Meng LQ, Li XM. “Therapeutic application and prospect of Astragalus membranaceus and Angelica sinensis in treating renal microvascular lesions”. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2008 Sep;28(9):859-61.[Article in Chinese].

15Wojcikowski K1, Wohlmuth H, Johnson DW. “Effect of Astragalus membranaceus and Angelica sinensis combined with Enalapril in rats with obstructive uropathy”. Phytother Res. 2010 Jun;24(6):875-84.

16Muthenna P1, Raghu G1, Kumar PA, et al. “Effect of cinnamon and its procyanidin-B2 enriched fraction on diabetic nephropathy in rats”. Chem Biol Interact. 2014 Oct 5;222:68-76.

17Mollazadeh H1, Hosseinzadeh H2. “Cinnamon effects on metabolic syndrome: a review based on its mechanisms”. Iran J Basic Med Sci. 2016 Dec;19(12):1258-1270.

18Kaffash Elahi R. “The effect of the cinnamon on dog’s heart performance by focus on Kortkoff sounds”. J Animal Veterinary. 2012;11:3604–3608.

19Dashti-Khavidaki S1, Shahbazi F, Khalili H, et al. “Potential renoprotective effects of silymarin against nephrotoxic drugs: a review of literature”. J Pharm Pharm Sci. 2012;15(1):112-23.

20Sedighifard Z1, Roghani F1, Bidram P, et al.  “Silymarin for the Prevention of Contrast-Induced Nephropathy: A Placebo-Controlled Clinical Trial”. Int J Prev Med. 2016 Jan 22;7:23.

21Sonnenbichler J, Scalera F, Sonnenbichler I, et al. “Stimulatory effects of silibinin and silicristin from the milk thistle Silybum marianum on kidney cells”. J Pharmacol Exp Ther. 1999 Sep; 290(3):1375-83.

22Wang XL1, Zhou FJ2, Dou M3, et al “Cochlearoids F-K: Phenolic meroterpenoids from the fungus Ganoderma cochlear and their renoprotective activity”. Bioorg Med Chem Lett. 2016 Nov 15;26(22):5507-5512.

23Joob B1, Wiwanitkit V2 Linzhi. “(Ganoderma lucidum); evidence of its clinical usefulness in renal diseases”. J Nephropharmacol. 2015 Dec 27;5(1):9-10.

24Du F1, Li S2, Wang T, et al. “Cordyceps sinensis attenuates renal fibrosis and suppresses BAG3 induction in obstructed rat kidney”. Am J Transl Res. 2015 May 15;7(5):932-40.

25Yu JS1,2,3, Ho CH4,5, Wang HY6,7, et al. “Acupuncture on Renal Function in Patients with Chronic Kidney Disease: A Single-Blinded, Randomized, Preliminary Controlled Study”. J Altern Complement Med. 2017 Apr 19.

26Matsumoto-Miyazaki J1, Miyazaki N1, Murata I, et al “Traditional Thermal Therapy with Indirect Moxibustion Decreases Renal Arterial Resistive Index in Patients with Chronic Kidney Disease”. J Altern Complement Med. 2016 Apr;22(4):306-14.

27Marsden S. “Introduction to veterinary acupuncture course notes’> College Integrative Veterinary Therapies, 2017.

 

 

Cat Periodontal Disease

As seen in Petrax

Cat periodontal disease, or gum disease in cats, is an inflammation of some or all of a tooth’s deep supporting structures. It is one of the most common diseases in cats today.

 

If food particles and bacteria are allowed to accumulate along a cat’s gumline, it can form plaque, which, when combined with saliva and minerals, will transform into calculus (tartar). This causes gum irritation and leads to an inflammatory condition called gingivitis.

 

Gingivitis, which is evidenced by a reddening of the gums directly bordering the teeth, is considered to be an early stage of periodontal disease in cats.

 

After an extended period, the calculus eventually builds up under the gum and separates it from the teeth. Spaces will form under the teeth, fostering bacterial growth.

 

Once this happens, the cat has irreversible periodontal disease. This usually leads to bone loss, tissue destruction and infection in the cavities between the gum and teeth.

 

Symptoms and Types of Gum Disease in Cats

 

Periodontal disease in cats generally begins with the inflammation of one tooth, which may progress if not treated during different stages of the condition.

 

A cat with stage 1 periodontal disease in one or more of its teeth, for example, will exhibit gingivitis without any separation of the gum and tooth.

 

Stage 2 is characterized by a 25 percent attachment loss, while stage 3 involves a 25 to 30 percent attachment loss.

 

In stage 4 of cat periodontal disease, which is also called advanced periodontitis, there is more than a 50 percent attachment loss. In the most advanced stage of the disease, the gum tissue will usually recede and the roots of the teeth will be exposed.

 

Cats may also develop a cat gum disease called stomatitis (gingivostomatitis). Stomatitis is the severe inflammation of all of the gum tissue, which may affect the other tissues in the mouth.

 

Stomatitis occurs due to an overactive immune response to even small amounts of plaque and calculus.

 

Causes of Gum Disease in Cats

 

Cat periodontal disease can be caused by a variety of factors,  but is most commonly associated with bacterial infection. Bacteria under the gumline leads to pain and inflammation of the tissue.

 

There may also be a relationship between having a history of calicivirus infection and severe gingivitis.

 

Diagnosis of Periodontal Disease in Cats

 

In the exam room, your veterinarian will look inside your cat’s mouth for red, inflamed gums. That is the first indication of a problem. Your veterinarian may press gently on the gums to see if they bleed easily, which is a sign that a deep dental cleaning, or more, is needed.

 

Once under anesthesia, the diagnosis of cat periodontal disease involves a number of procedures. If periodontal probing reveals more than one millimeter of distance between the gingivitis-affected gum and tooth, a cat is considered to have some form of periodontal abnormality.

 

X-rays are extremely important in diagnosing periodontal disease in cats because up to 60 percent of the symptoms are hidden beneath the gumline.

 

In the disease’s early stages, X-rays will reveal loss of density and sharpness of the root socket (alveolar) margin. In more advanced stages, it will reveal loss of bone support around the root of the affected tooth.

 

Treatment

 

The specific treatment for cat periodontal disease depends on how advanced the disease is. In the early stages, treatment is focused on controlling plaque and preventing attachment loss.

 

This is achieved through daily brushing with pet-safe toothpaste, professional cleaning and polishing, and the prescribed application of fluoride or other pet prescription products to minimize the development of plaque.

 

Sometimes it is necessary to remove the teeth associated with severe stomatitis.

 

In the more advanced stages, bone-replacement procedures, periodontal splinting and guided tissue regeneration may become necessary.

 

Living and Management

 

Follow-up treatment for periodontal disease in cats consists mostly of maintaining good cat dental care and taking your cat for weekly, quarterly or biannual checks.

 

The prognosis will depend on how advanced the cat gum disease is, but the best way to minimize the adverse effects caused by the disease is to get an early diagnosis, adequate treatment and proper therapy.

 

Prevention

 

The best prevention for cat gum disease is to maintain your pet’s good oral hygiene and to regularly brush and clean her mouth and gums.

 

Cats can be trained to accept brushing when trained slowly over time and rewarded for their cooperation.

 

Prescription cat food dental diets are available for those cats who are unwilling to have their teeth brushed.

 

Cat dental treats, water additives and other products certified by the Veterinary Oral Health Council (VOHC) are also shown to help reduce plaque and calculus.

 

5 Weird Things Cats Love

By Dr. Wailani Sung comments by Diane Weinmann

Everyone has behavioral quirks, and sometimes it appears that our cats have them, too. Do you find it unusual that you buy expensive cat toys and your cat would rather play with a simple hair tie?

 

Cats may be mysterious creatures, but there’s usually a reason behind their behaviors or an explanation for their interests. If you’re curious as to why your cat likes the weird things he does, then keep reading for insight on the motivation behind your cat’s fascination.

 

Drinking From Your Water Cup or the Faucet Instead of Their Fountain

 

So, you purchase an expensive cat water fountain and your cat likes to drink out of your glass or from the faucet. Why does he do that?

 

Your cat may not realize that your glass of water is your glass of water. He just may find it convenient that there is a vessel that contains water when he is thirsty, so he drinks from it. Cats in the wild will drink whenever they are thirsty and find a water source; they do not specifically look around for bowls of water.

 

Another perspective may be that your cat watches you drink, and she wants to drink what you are drinking. If it is good enough for you, it is good enough for her.

 

Some cats may prefer to drink from the faucet when you are busy washing dishes or brushing your teeth due to their fascination by water that suddenly appears.

 

Or, your cat may just have a taste preference for running water compared to water that has been sitting in a cat bowl all day, which leads to bacteria formation. Plus, food particles may fall in and change the taste of the water.

 

This is the reason why your cat’s water bowl should be changed several times a day and washed with soap and water at least daily.

 

Pushing Things Off Tables and Watching Them Break

 

Do you have a cat that just lives to knock things off your shelf? It is so frustrating to provide your cat with plenty of toys, only to have her knocking items off of counters and breaking things on a daily basis. Why do cats feel the need to do this?

 

Well, every time your cat pushes an item until it drops, it reacts in a different manner. It may just be fun for him to watch the items bounce around in different directions each time they fall or watch them shatter to multiple pieces.

 

One time, my cat was mad at my husband, so he wound his way through very fragile breakable items on a sofa table that belonged to me to go to a very expensive one of a kind object that belonged to my husband and swiped it onto the floor!  LOL

 

Getting Into Boxes and Jumping Out of Them

 

Why are some cats obsessed with boxes? They are creatures of comfort, and sometimes being in a box with side support is comfortable. Other times, being in a box makes some cats feel safe and secure, like they are protected from all sides.

 

Boxes are also fun to hide in, spring out and surprise people and other pets in the household. I think the cats are secretly amused by the look of surprise or terror on our faces or the reactions from their housemates when they catch us unaware. Just like some people like to pull pranks, this is their way of pranking us.

 

Paper bags from the grocery store were great entertainment for Diane’s cat Milo.  She always had to be careful when picking them up off the floor because they frequently contained the cat!

 

Stalking Inanimate Electrical Cords

 

My cat is fascinated by electrical cords. Every night as we sit and watch television, I see him make the rounds around the living room. He bats at the tags attached to the cords. Then he grabs the cords and tries to bite it.

 

You would think that by now he would be bored with the game. Why would he keep doing it?

 

A reason may be that he might have learned that playing with the cord was a good way of getting my attention. Playing with the cord may also be fun because it moves in different and unexpected ways, which piques his interest.

 

By now I know his MO (modus operandi). So, I now pre-emptively get his attention and distract him with a cat feather wand, or we play a game of fetch to take his mind of off hunting the cord.

 

Having Their Butt Scratched

 

Have you ever had a cat walk up to you, turn around, and present their tail end? The area just above the tail that we would call the “butt” is an area that a cat cannot use its paws to scratch, and sometimes using your tongue to scratch does not do the trick.

 

Some cats have learned to back up against a dangling hand if they want a good scratch. Cats might indicate their enjoyment by purring, twitching their tails, raising their butts and sometimes arching up against your hand or foot.

 

What we see as quirky cat behaviors are normal cat behaviors that they need to express or those that are inadvertently reinforced. So relax and enjoy your cat’s unique personality!

 

Hyperthyroidism in Cats

Hyperthyroidism in Cats

By Dr. Karen Becker

Recent research has revealed that yet another chemical substance found in households may be contributing to feline hyperthyroidism, a disease that affects a significant percentage of cats over the age of 10. The chemicals are called per- and polyfluoroalkyl substances (PFAS), and they are widely used as water and oil repellents. According to ScienceDaily:

“PFAS are a family of more than 3,000 structures of highly fluorinated chemicals used in industrial processes and consumer products, such as protective coatings for carpets, furniture and apparel, paper coatings, insecticide formulations, and other items.”1

PFAS are used in many industrial applications calling for nonstick or slick surfaces, such as food packaging, stain- and water-resistant fabrics, nonstick cookware and firefighting foam. These chemicals are now ubiquitous in our environment, having migrated into the air, household dust, food, soil, and ground, surface and drinking water.

Study Links PFAS Chemicals to Hyperthyroidism in Cats

For the study, a team of researchers at the California Environmental Protection Agency looked at blood levels of PFAS in two separate groups of Northern California kitties, most of which were at least 10 years old. The first group of 21 was evaluated between 2008 and 2010; the second group of 22 was sampled between 2012 and 2013.2

The researchers observed that the higher the blood levels of PFAS, the more likely the cat was to be hyperthyroid. One type of PFAS in particular, perfluorooctanoic acid (PFOA) was significantly higher in hyperthyroid kitties. These findings “… may indicate a possible link between PFAS levels and cat hyperthyroid, warranting a larger study for further investigation,” according to the research team.

In a bit of good news, the scientists noted a slight decline in PFAS blood levels between the first group of cats tested eight to 10 years ago, and the second group tested more recently. This mirrors recent results in humans as more companies phase out use of these chemicals, and presumably, as people gradually replace PFAS-treated household items.

Reducing Your Family’s and Pet’s Exposure to PFAS

Your best bet is to avoid all products that contain or were manufactured using PFAS, which will typically include products that are stain-resistant, waterproof or nonstick. From the Environmental Working Group:3

Find products that haven’t been pre-treated and skip optional stain-repellent treatment on new carpets and furniture
Cut back on fast food and greasy carryout food, since these foods often come in PFC-treated wrappers
Especially when buying outdoor gear, choose clothing that doesn’t carry Gore-Tex or Teflon tags, and be wary of all fabrics labeled stain- or water-repellent
Avoid nonstick pans and kitchen utensils — opt for stainless steel or cast iron instead
Pop popcorn the old-fashioned way, on the stovetop, since microwaveable popcorn bags are often coated with PFCs on the inside.
Choose personal care products without “PTFE” or “fluoro” ingredients; also avoid Oral-B Glide floss, which is made by Gore-Tex

It’s also important to filter your pet’s drinking water, and yours, to remove contaminants such as fluoride, chlorine, heavy metals and others. Household tap water typically contains enough toxic minerals, metals, chemicals and other unhealthy substances to damage your pet’s health long term.

Flame Retardants: Another Enemy of Indoor Kitties

Polybrominated diphenyl ethers (PBDEs), or flame retardants, are another type of household chemical that has been linked to overactive thyroid in cats, and a 2017 study confirmed the results of earlier studies that prove the high levels of PBDEs measured in indoor kitties are from house dust.4

PBDEs have been used since the 1970s in textiles, electronics and furniture to prevent them from burning, but like PFAS, they aren’t chemically bound to the product material, so they drift into the environment and cling to particles in the air such as house dust.

A number of these chemicals have been banned for use in household products, but they are extremely persistent and can leach into the environment for many years. Contaminated household dust can be inhaled as well as ingested, and can have an adverse effect on the health of kitties.

Brominated Flame Retardants Are Known Endocrine Disruptors

Prior studies of PBDE blood levels in cats have focused primarily on potential causes of feline hyperthyroidism, however, the intent of this study was to measure levels in healthy cats to establish their dust exposure.

The researchers took “paired samples” from the homes of each of the cats, meaning they took both dust samples and blood samples at the same time. They found evidence not only of brominated and chlorinated contaminants currently in use, but also chemicals that have been banned for decades. According to study co-author Jana Weiss, Ph.D.:

“By taking paired samples, we have greater insight into the environment that the cats live in. Moreover the cats in the study spent the majority of their time indoors and therefore air and dust in the home is expected to contribute more than the outdoor environment.”5

The study results are a heads up not only for cat guardians, but also anyone with small children, because both kitties and kiddos engage in a lot of “hand-to-mouth activities.”

“The brominated flame retardants that have been measured in cats are known endocrine disruptors. It’s particularly serious when small children ingest these substances because exposure during development can have consequences later in life, such as thyroid disease,” said Weiss.

Minimizing PDBE Exposure at Home

Most new foam products are not likely to have PBDEs added. If you have foam items in your home, office or vehicle that were purchased before 2005, however, they probably contain PBDEs. The Environmental Working Group offers the following tips to help limit your family’s and pet’s exposure to PBDE-containing products:6

Whenever possible choose PBDE-free electronics and furniture; PBDEs shouldn’t be in mattresses, couches and other foam products sold in 2005 or later, however they’re still put in some new televisions and computer monitors
Avoid contact with decaying or crumbling foam that might contain fire retardants, including older vehicle seats, upholstered furniture, foam mattress pads, carpet padding and kid’s products made of foam
Use a high-efficiency particulate air (HEPA) filter vacuum cleaner, since these vacuums capture the widest range of particles and are also good for reducing lead or allergens in house dust
Replace couches, stuffed chairs, automobile seats and the like that have exposed foam (if you can’t afford to replace them, cover them with sturdy cloth and vacuum around them frequently)
Don’t reupholster your older foam furniture, especially in homes where children or pregnant women live
Be careful when removing or replacing old carpet, since PBDEs are found in the foam padding beneath carpets; isolate the work area with plastics, and avoid tracking construction dust into the rest of your house
The replacement chemicals for PBDEs in foam are not fully tested for their health effects, so buy products made with natural fibers (like cotton and wool) that are naturally fire-resistant and may contain fewer chemicals

Did You Know PBDEs Are Also in Commercial Cat Food?

The same researchers who published the 2017 study I mentioned earlier also measured PBDE levels in cat food (both canned and kibble) matching the diets of the kitties in the study. They found that blood levels of PBDEs in the cats also significantly correlated with concentrations of those chemicals in the cat food.

In addition, another recent study concluded that fish-flavored cat food is a problem.7 A team of Japanese scientists evaluated cat food and feline blood samples and discovered that the type of polychlorinated biphenyl (PCB) and PBDE byproducts found in both the food and blood samples are derived from marine organisms.

The researchers were also able to simulate the way in which the bodies of cats convert the type of chemical present in the food into the type of chemical seen in the cats’ blood samples.

Based on their results, the team concluded the byproducts detected at high levels in cats’ blood samples likely came from fish-flavored food and not exposure to PCBs or PBDEs. However, further work is needed to determine the link between the metabolites (byproducts) and hyperthyroidism. If you’re wondering how these chemicals wind up in fish-flavored cat food, Dr. Jean Hofve of Little Big Cat explains it very well:

“There is a link between the feeding of fish-based cat foods and the development of hyperthyroidism, which is now at epidemic levels. New research suggests that cats are especially sensitive to PBDEs … [which are] found at higher levels in both canned and dry cat foods than dog foods; and more in dry than canned cat foods.

Fish-based foods are even worse, because marine organisms produce PDBEs naturally and can bioaccumulate up the food chain to high levels in fish; this compounds the exposure cats get from fabrics and dust.”8

5 Tips to Help Prevent Hyperthyroidism in Your Cat

  1. Rid your environment of flame-retardant chemicals
  2. Provide an organic pet bed
  3. Feed a nutritionally balanced, fresh, species-appropriate diet to control iodine levels in your cat’s food, since iodine has also been linked to hyperthyroidism
  4. Avoid feeding your cat a fish-based diet, since seafood is a very rich source of iodine, and cats aren’t designed to process a lot of iodine
  5. Avoid feeding soy products to your kitty, as they have also been linked to thyroid damage

I also recommend checking your cat’s thyroid levels annually after the age of 7.